Accession Number:

ADA467933

Title:

Antioxidant Prophylaxis in the Prevention of Prostatic Epithelial Neoplasia

Descriptive Note:

Annual rept. 1 Feb 2005-31 Jan 2006

Corporate Author:

TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO

Report Date:

2006-02-01

Pagination or Media Count:

7.0

Abstract:

The Pls laboratory has relocated to the University of Texas Health Science Center San Antonio TX. This is a report of the work that was conducted at AMC Cancer Research Center Denver CO between March 1 and June 30, 2005. We have submitted a report describing the work performed in Yl of the project in Feb 2005. This 4 month February 26th 2005 to June 30th 2005 report describes the research accomplishments primarily associated with the Task I as outlined in the approved statement of work. As mentioned in the Yl report we terminated the experiment involving feeding antioxidant supplemented diet in May 2005 as described in our Yl report. At the termination of the study 16 weeks serum, prostate and other organs were collected from all the animals. The efficacy of the combination of antioxidants was assessed by histological evaluation of the prostate and modulation of antioxidant enzymes. Data indicate that 90 of the animals in the control group developed high grade PIN while only 10 of the animals in the experimental group developed high grade PIN. In contrast 90 of the animals on the experimental diet developed low grade PIN. This suggests that a combination of antioxidants can reduce or delay the appearance of high grade PIN in Noble rats. Detailed studies to understand the mechanism of action of these antioxidants as proposed are currently in progress.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Food, Food Service and Nutrition

Distribution Statement:

APPROVED FOR PUBLIC RELEASE