Role of Obesity in Prostate Cancer Development
Annual rept. 1 Feb 2006-31 Feb 2007
MINNESOTA UNIV MINNEAPOLIS
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Prospective epidemiological studies indicate that obesity increases the risk for prostate cancer. Also, mortality from prostate cancer is increased with elevated body weights and obesity recently was reported to be associated with higher prostate cancer grade at diagnosis and with higher recurrence rates. However, it is difficult in human studies to adequately assess effects of body weight or the effect of body weight change at specific ages on prostate cancer. Recent introduction of the TRAMP transgenic adenocarcinoma mouse prostate mouse provides a model that shares many characteristics with human prostate cancer. In the present study we assessing the effect of obesity induced at different ages on the development of prostate cancer in TRAMP mice. Obesity is induced in TRAMP mice by injections with gold-thioglucose GTG at either 6, 16 or 26 weeks of age. Body weight is monitored and longitudinal blood samples are obtained to monitor serum leptin levels. Mice are followed until 46 weeks of age. The 26-week cohort study is complete and preliminary analyses of the data indicate no effect of body weight on prostate tumor development although pathology results have not been obtained. Mice in the 6- and 16- week cohorts are currently being followed.
- Medicine and Medical Research