Process Research and Development of Antibodies as Countermeasures for C. Botulinum
Annual rept. 1 Mar 2004-28 Feb 2005
NEBRASKA UNIV LINCOLN
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This report describes the project to fill out shell space on the third floor of Othmer Hall, the new home for the University of Nebraska-Lincoln Biological Process Development Facility. Construction is 95 completed and all research laboratories of the BPDF are functional. The 5 includes a Master Cell Banking. The third floor is home to all process research capabilities, i.e. molecular biology, fermentation, cell culture, analytical methods, quality control, purification development, media prep, and two academic laboratories in the department of chemical engineering performing bioengineering research. The contract for detailed design of the cGMP basement was awarded June 2004 and is expected to be completed by Fall 2005. This report also describes research on the expression of an antibody against serotype A botulinum neurotoxin in Chinese Hamster Ovary CHO. Research on new expression plasmids, development of a serum-free media, and optimization of a fed-batch process to produce the antibody against.
- Medicine and Medical Research