Accession Number:

ADA467837

Title:

Scavenger Receptors and Resistance to Inhaled Allergens

Descriptive Note:

Annual rept. 17 Jan 2006-16 Jan 2007

Corporate Author:

HARVARD UNIV CAMBRIDGE MA

Personal Author(s):

Report Date:

2007-02-01

Pagination or Media Count:

26.0

Abstract:

After OVA sensitization and aerosol challenge, SR-AIII and MARCO-deficient mice exhibited greater eosinophilic airway inflammation and airway hyper responsiveness compared to wild-type mice. A role for simple SRA-mediated antigen clearance scavenging by lung macrophages was excluded by observation of comparable uptake of fluorescent OVA by wild-type and SRA-deficient lung Mphis and DCs. In contrast, airway instillation of fluorescent antigen revealed significantly higher traffic of labelled DCs to thoracic lymph nodes in SRA-deficient mice than in controls. The increased migration of SRA-deficient DCs was accompanied by enhanced proliferation in thoracic lymph nodes of adoptively transferred OVA-specific T cells after airway OVA challenge. The data identify a novel role for SRAs expressed on lung DCs in down-regulation of specific immune responses to aero-allergens by reduction of DC migration from the site of antigen uptake to the draining lymph nodes.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE