Accession Number:

ADA467829

Title:

Targeted Therapies for Myeloma and Metastatic Bone Cancers

Descriptive Note:

Annual rept. 18 Jan 2006-17 Jan 2007

Corporate Author:

SOUTHWEST RESEARCH INST SAN ANTONIO TX

Personal Author(s):

Report Date:

2007-02-01

Pagination or Media Count:

36.0

Abstract:

Developed two procedures for preparing nanoparticles and demonstrated their ability to repeatedly produce nanoparticles with narrow distribution in the target particle size range of 70-200nm and smaller, if necessary. Synthesized and fully characterized PLA-b-PEG-Maleimide block copolymers to facilitate the attachment of bone-targeting ligands to polymer nanoparticles via thiol coupling. Improved lyostability of polymer nanoparticles, with and without PEG modification. Developed methods to radiolabel polymer nanoparticles, the first time, to our knowledge, this has been done. Encapsulated two proteasome inhibitors, MG-132 and PS-1, and determined their in vitro release profiles. Developed proteasome activity assay to determine activity of encapsulated drug. Developing in vitro assay to determine affinity of bone-targeting nanoparticles to hydroxyapatite substrates.

Subject Categories:

  • Medicine and Medical Research
  • Polymer Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE