Accession Number:

ADA467775

Title:

Early Detection of Prostate Cancer

Descriptive Note:

Final addendum rept. 1 May-31 Dec 2006

Corporate Author:

WESTERN MICHIGAN UNIV KALAMAZOO

Personal Author(s):

Report Date:

2007-01-01

Pagination or Media Count:

95.0

Abstract:

Acoustic wave sensors have been widely used for detection of various chemical and biological species in liquid media. An improved binding of Protein A and IgG molecules on QCM biosensors by modifying the gold surface of the quartz crystal with a 35nm polystyrene film followed by an acidic treatment was accomplished. Also, the increase in the sensitivity of the QCM biosensor with CNT as the chemical interface was studied. Immobilization of the PSA at different concentrations on gold surface was achieved and corresponding sensor responses were registered. Using ELISA technique it was verified that PSA was bound to both the crystals and the 96 well plates. Following this, SH-SAW devices have been designed in a differential configuration to be used as biosensors with high selectivity. These SH-SAW devices were fabricated at the Microfabrication facility at University of Michigan, Ann Arbor. The frequency response of these SH-SAW devices and their performance when used in the oscillator configuration has also been recorded. A complete physical structure which can house the sensor along with the associated analog circuitry has been designed and developed. This structure provides electromagnetic shielding as well as reducing the effects of vibration and motion to the entire sensing system.

Subject Categories:

  • Medicine and Medical Research
  • Acoustic Detection and Detectors

Distribution Statement:

APPROVED FOR PUBLIC RELEASE