Accession Number:

ADA467583

Title:

Neurofibromatosis and the Painful Neuroma

Descriptive Note:

Annual rept. 1 Jan-31 Dec 2006

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s):

Report Date:

2007-01-01

Pagination or Media Count:

24.0

Abstract:

Pain is a common and distressing symptom that impacts the quality of life of many patients with neurofibromatosis. The pain is often due to the formation of a neuroma. To understand better how neuromas cause pain and what treatments may be provided, we have attempted to develop an animal model of a painful neuroma. We have completed the first of the three specific aims in this research project. The tibial neuroma transposition TNT model has been confirmed as a model of neuropathic pain. The TNT model has been established as reliable and valid. In the TNT model, the neuroma test-site mechanosensitivity is dependent on neural input from the tibial neuroma. In the TNT model, hindpaw mechanical hyperalgesia is independent of input from the tibial neuroma. We will now move on with work related to developing methods to prevent painful neuroma formation.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE