Accession Number:

ADA467572

Title:

Analysis of p21-Activated Kinase Function in Neurofibromatosis Type 2

Descriptive Note:

Annual rept. 1 Jan 2006-31 Dec 2006

Corporate Author:

INSTITUTE FOR CANCER RESEARCH PHILADELPHIA PA

Personal Author(s):

Report Date:

2007-01-01

Pagination or Media Count:

7.0

Abstract:

The goal of this project is to determine if group A p21-activated kinases Paks are important elements in signaling in neurofibromatosis type II NF2. Our hypothesis is that activation of the NF2 gene disrupts a signaling pathway emanating from the small GTPase Rac and its effector, p21-activated kinase Pak. We propose that stimulation of the RacPak signaling axis in cells lacking Merlin leads to changes in transcriptional activity and cytoskeletal dynamics, ultimately resulting in enhanced cell proliferation and motility, which are hallmarks of tumorigenesis.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE