Accession Number:

ADA467564

Title:

Differential Mechanisms of Androgen Resistance

Descriptive Note:

Annual summary rept. 22 Nov 2005-21 Nov 2006

Corporate Author:

MICHIGAN UNIV REGENTS ANN ARBOR DIV OF RESEARCH DEVELOPMENT AND ADMINISTRATION

Personal Author(s):

Report Date:

2006-12-01

Pagination or Media Count:

11.0

Abstract:

We proposed to study the mechanisms of androgen resistance by focusing on androgen receptor mutations and may arise due to selective pressures of antiandrogen treatment. We have utilized xenograft and a humanized mouse model of prostate cancer. To date we have identified mutations throughout the androgen receptor coding region and are in the process of carrying out functional analysis. It is proposed that these mutations may lead to greater androgen receptor activity under particular conditions and potentially highlight sites of interaction with critical coactors that might themselves serve as novel therapeutic targets to complement androgen ablation. During this study analysis of tumor progression in the hmAR X TRAMP mice have highlighted differences in disease course between antiandrogen treated and hormone deplete castrated mice. We are in the process of determining mechanisms underlying these differences by characterizing AR levels and subcellular localization in these tumors

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE