Accession Number:

ADA467561

Title:

Activation and Protection of Dendritic Cells in the Prostate Cancer Environment

Descriptive Note:

Annual rept. 15 Jan 2006-14 Jan 2007

Corporate Author:

UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY NEWARK

Personal Author(s):

Report Date:

2007-02-01

Pagination or Media Count:

26.0

Abstract:

First annual report for this award. Experiments were conducted as was scheduled in the Statement of Work. So far studies have demonstrated for the first time the presence of endothelin receptors on murine DC and the fact of endothelin-I production by murine DC upon stimulation with TNFdot. Phenotyping of dendritic cells stimulated with TNFdot and treated with endothelin receptor inhibitors demonstrated decreased expression of pro-inflammatory co-stimulatory molecules CD40 VD80 CD86 CD205 MHC class II with the blockade of ETA receptors and no change or mild increase in the expression of co-stimulatory molecules with the blockade of ETB receptors. In vivo administration of endothelin A receptor inhibitor abolished the effect of infectious stimulus to mobilize dendritic cells to draining lymph nodes. Functional studies are under way to further characterize the role of endothelin receptors in the biology of dendritic cells as well as to study the interaction of dendritic cells and prostate cancer cells and develop the means of active cell therapy for murine prostate cancer model.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE