Integration of Soluble and Adhesive Gradient Signals in Directed Cell Migration
Final technical rept., 1 Jun 2003-30 Nov 2006
NORTH CAROLINA STATE UNIV AT RALEIGH
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Our research has led to a comprehensive model of fibroblasts responsiveness to PDGF gradient stimulation at the level of PI 3-kinase signaling, and we have analyzed the implications of this mechanism for dermal wound invasion. In this research, we have utilized and in some cases developed advanced tools for live-cell microscopy and quantitative analysis including mathematical modeling. Thus, our research has contributed to the fundamental understanding of directed fibroblast migration, a critical process in wound healing.
- Medicine and Medical Research