Accession Number:

ADA467054

Title:

Integration of Soluble and Adhesive Gradient Signals in Directed Cell Migration

Descriptive Note:

Final technical rept., 1 Jun 2003-30 Nov 2006

Corporate Author:

NORTH CAROLINA STATE UNIV AT RALEIGH

Personal Author(s):

Report Date:

2006-11-01

Pagination or Media Count:

5.0

Abstract:

Our research has led to a comprehensive model of fibroblasts responsiveness to PDGF gradient stimulation at the level of PI 3-kinase signaling, and we have analyzed the implications of this mechanism for dermal wound invasion. In this research, we have utilized and in some cases developed advanced tools for live-cell microscopy and quantitative analysis including mathematical modeling. Thus, our research has contributed to the fundamental understanding of directed fibroblast migration, a critical process in wound healing.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE