The Effects of Repeated Low-Dose Sarin Exposure
Technical rept. Jan 2000-Apr 2002
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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This project assessed the effects of repeated low-dose exposure of guinea pigs to the organophosphorus nerve agent sarin. Animals were injected once a day, 5 days per week Monday-Friday, for 2 weeks with fractions 0.3 x, 0.4 x, 0.5 x or 0.6 x of the established LD50 dose of sarin 42 microgramskg, s.c.. Animals were assessed for changes in body weight, red blood cell RBC acetylcholinesterase AChE levels, neurobehavioral reactions to a functional observational battery FOB, cortical electroencephalographic EEG power spectrum, and intrinsic acetylcholine ACh neurotransmitter NT regulation over the 2 weeks of sarin exposure and for up to 12 days post-injection.
- Chemical, Biological and Radiological Warfare