Accession Number:

ADA465906

Title:

The Effects of Repeated Low-Dose Sarin Exposure

Descriptive Note:

Technical rept. Jan 2000-Apr 2002

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Report Date:

2005-08-01

Pagination or Media Count:

38.0

Abstract:

This project assessed the effects of repeated low-dose exposure of guinea pigs to the organophosphorus nerve agent sarin. Animals were injected once a day, 5 days per week Monday-Friday, for 2 weeks with fractions 0.3 x, 0.4 x, 0.5 x or 0.6 x of the established LD50 dose of sarin 42 microgramskg, s.c.. Animals were assessed for changes in body weight, red blood cell RBC acetylcholinesterase AChE levels, neurobehavioral reactions to a functional observational battery FOB, cortical electroencephalographic EEG power spectrum, and intrinsic acetylcholine ACh neurotransmitter NT regulation over the 2 weeks of sarin exposure and for up to 12 days post-injection.

Subject Categories:

  • Toxicology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE