Accession Number:

ADA465853

Title:

The Role of Beta-Catenin in Androgen Receptor Signaling

Descriptive Note:

Annual rept. 16 Jan 2004-30 Sep 2005

Corporate Author:

VANDERBILT UNIV NASHVILLE TN

Personal Author(s):

Report Date:

2005-10-01

Pagination or Media Count:

10.0

Abstract:

Dr. Truica previously showed that the cell adhesion molecule beta-catenin forms a complex with the androgen receptor AR and modulate its transcription. The cross talk between beta- catenin and AR signaling can play an important role in AR transcriptional in prostate cancer progression. Our preliminary data seem indicate stromally derived paracrine Wnt family members activate the epithelial frizzled receptor to enable prostate epithelial survival in an androgen deficient environment. We will continue to test the original hypothesis that there is a direct molecular interaction between -catenin and the Cterminus region of AR involved in the mechanism of prostate androgen responsiveness. However, we will examine the repercussions of the interaction in both LNCaP originally proposed and primary cultures of mouse prostatic stromal cells. The physiologic response to androgen ablation castration differ significantly between the prostatic stroma and epithelia despite the common expression of -catenin and AR, as evidence for the different transcriptional cofactor interactions found in prostatic epithelial and stromal cells. The future work will adhere to the previously approved tasks and those detailed in the body of this report with the additional examination of prostatic stromal cells.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE