Seamless Integration of Detection and Therapy for Breast Cancer using Targeted Engineered Nanoparticles
Annual rept. 15 May 2005-14 May 2006
RICE UNIV HOUSTON TX
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This report summarizes the efforts of our team consisting of researchers from Rice University and M. D. Anderson Cancer Center, in the DoD funded CDMRP award towards the development of an integrated nano particle based imaging and therapy of breast cancer. We have used both gold nano particles Au-NPs and gold nanoshells for specifically targeting cancer cells. This has been accomplished in two ways. First by attaching anti-human epidermal growth factor receptor 2 anti-HER 2 antibodies to gold nanoshells for targeting HER 2 expressing SK-BR3 breast carcinoma cells. The second approach is by building biologically active networks of Au-NP and bacteriophages which can be used as in vivo biological sensors for non invasive optical molecular fingerprinting, and cell targeting agents.
- Medicine and Medical Research