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Analysis of Ethnic Admixture in Prostate Cancer

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Annual rept. 30 Nov 2005-29 Nov 2006

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Evidence for a genetic component to prostate cancer is strong however few genes have been identified and most of the genetic risk remains undefined. To date multiple traditional genome scans and linkage analyses have been performed and several susceptibility loci and candidate genes have been identified. The goal of this research proposal is to use a novel approach to gene discovery admixture mapping to identify potential prostate cancer susceptibility genes in a group of African American men. Admixture mapping has greater power to detect genetic effects than traditional genome linkage scans. Recently Freedman et al. published results from an admixture mapping study of prostate cancer in 1597 African American men which detected a susceptibility region on chromosome 8q24. In the current study approximately 900 samples from 2 case-control study of prostate cancer are being genotyped for ancestry informative markers across the genome using a similar marker panel to that used by Freedman et al. Regions showing strong linkage using the admixture mapping approach will be followed by future studies using fine mapping with a denser set of informative markers in the regions of interest and candidate gene studies. After 12 months the project is on time with completion of the targeted tasks outlined in the Statement of Work for the projects first year, and is on track to complete all tasks within the next 12 months, as planned.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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