Functional Analysis of Human NF1 in Drosophila
Annual rept. 15 Dec 2005-14 Dec 2006
COLD SPRING HARBOR LAB NY
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Neurofibromatosis type 1 NFI is characterized by benign but disfiguring skin tumors, pigmentation defects and learning disabilities, as well as increased risk of brain tumors. The NF1 tumor suppressor protein neurofibromin inhibits Ras, a protein that is overactive in a wide variety of human cancers. NF1 also controls levels of cyclic AMP, an important intracellular messenger involved in cell growth and learning. Over last year, we continue to examine the structural basis for its role in controlling multiple signal transduction pathways and roles in learning and memory formation. In addition to previously identified GAP related domain, we showed that the C-terminal is critical in mediating G protein dependent activation of adenylyl cyclase. We are now examining the functional roles of these two domains in learning and memory.
- Anatomy and Physiology
- Medicine and Medical Research