Accession Number:

ADA465168

Title:

Neural Control of Hemorrhage-Induced Tissue Cytokine Production

Descriptive Note:

Final technical rept. Mar 2000-Dec 2006

Corporate Author:

LOUISIANA STATE UNIV HEALTH SCIENCES CENTER NEW ORLEANS DEPT OF PHARMACOLOGY

Personal Author(s):

Report Date:

2007-03-31

Pagination or Media Count:

5.0

Abstract:

Studies performed under this grant provided evidence that tissue injury and hypoperfusion activate systemic and central neural, hormonal and opiate mechanisms that regulate the hemodynamic, metabolic and proinflammatory counter regulatory responses involved in restoring homeostasis following traumahemorrhage. Opiate pathway activation favors hemodynamic instability and a pro-inflammatory tissue response while sympathetic nervous system activation counteracts the inflammatory response and contributes to cardiovascular responsiveness. Our studies demonstrated that the intact neuroendocrine response is critical to ensure survival and host defense mechanisms from secondary infectious challenges. Furthermore, stress-and analgesia-induced disruptions in response exacerbate hemodynamic instability, compromise tissue perfusion and predispose to tissue injury and impaired innate host-defense response to a subsequent challenge.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE