Accession Number:

ADA464404

Title:

Identification of Biomarkers Associated with the Healing of Chronic Wounds

Descriptive Note:

Annual rept. 15 Jun 2005-14 Jun 2006

Corporate Author:

DAEMEN COLL AMHERST NY

Personal Author(s):

Report Date:

2006-07-01

Pagination or Media Count:

24.0

Abstract:

It is the objective of this study to identify the biomarkers associated with the earliest stages of healing in chronic wounds. The findings of this study are intended to facilitate the development a diagnostic tool which would evaluate the healing process. Samples have been collected from interior and peripheral wound sites over 6 weeks from 17 subjects thus far and analyzed using 2-D page. 161 spotsproteins have been identified that change over time in chronic wounds. The peripheral and interior sites sampled have different proteins present. Some proteins were present only in interior samples and not peripheral samples and vice versa. A series of shadow spots have been identified and linked with healing in chronic wounds. A number of experimental protocols have been developed during this first year including two data analysis methods. The identification of a series of shadow proteins which appear in wounds healing and disappear during non-healing periods, is the first important step in the identification of biomarkers associated with healing chronic wounds.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE