Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography
Annual rept. 1 Apr 2004-31 Mar 2006
CITY UNIV OF NEW YORK RESEARCH FOUNDATION
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The research carried out during the current reporting period included a Setting up of the near-infrared optical imaging experimental arrangements, b Development of an approach for optical tomographic imaging using independent component analysis OPTICA, c Development of a tomographic image reconstruction approach using the round-trip matrix approach, and, d Target detection and localization using the combined experimental and theoretical approaches. OPTICA is applicable for detection and localization of scattering, absorptive, and fluorescent targets and was demonstrated to provide locations of targets in model media, breast phantoms, and model breasts assembled using ex vivo human breast tissues with millimeter accuracy. The round-trip matrix approach could locate 6 targets embedded in a turbid medium that is 50 transport mean free path thick in simulation. These results have potential applications in obtaining accurate location of tumors within breast, as well as, in lumpectomy.
- Medicine and Medical Research