Molecular and Clinical Predictors of Aggressive Prostate Cancer
Annual rept. 1 Sep 2005-31 Aug 2006
BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
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The current project seeks to study molecular and clinical predictors of aggressive prostate cancer in two large US cohorts of prostate cance cases from the Physicians Health Study PHS and the Health Professionals Follow-up Study HPFS. We have almost completed review of medical records for the more than 6,000 prostate cancer cases in the cohort, to abstract clinical data, and are assembling a clinical datafile. Among the 900 cases on whom tumor tissue are contained on 8 tissue microarrays, we have undertaken immunohistochemistry to assess protein expression for five genes as part of a recently identified molecular signature associated with lethal prostate cancer. Intensity and percent staining for these five markers has been evaluated by the pathologist for the PHS cases, and statistical analyses are underway to assess the association of the molecular signature to predict poor prostate cancer survival. The statistical team has discussed model building strategies for both sets of markers.
- Anatomy and Physiology
- Medicine and Medical Research