Sage Gene Expression Profiles Characterizing Cure
Annual rept. 6 Sep 2004-5 Sep 2005
DORN RESEARCH INST INC COLUMBIA SC
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The menstrual cycle phase of breast cancer resection affects the frequency of cancer metastatic spread. Tumor metastases are 2-3 fold more frequent when the resection is performed during diestrus as compared to estrus. Tumor angiogenesis is essential for both cancer growth and lethal metastatic cancer spread. The balance between vascular endothelial growth factor VEGF and basic fibroblast growth factor bFGF modulates new blood vessel formation and blood vessel permeability. In a nonbreast tumor, methylcholantrenenemeth. The changes in breast cancer capillary permeability, VEGF and bFGF that occur during each fertility cycle, in breast tissue and breast cancer, putatively in response to cyclical changes in sex hormones, may contribute, at least in part, to both the modulation of cancer growth and post-resection breast cancer spread by the fertility cycle. We hypothesize that there are characteristic patterns of tumor cell gene expression that change throughout the menstrual estrous cycle, and that a subset of these cycling genes are in part associated with, and responsible for the changes in curability of resected breast cancers. We investigated the influence of the estrous cycle on breast tumor surgical cure and metastatic spread to the lungs, using a primary, transplantable, mammary carcinoma, resected for surgical cure from young, sexually mature cycling C3HeBFeJ female mice at each of 4 fertility cycle stages.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research