Accession Number:

ADA464007

Title:

Dietary Fish Oil in Reducing Bone Metastasis of Breast Cancer

Descriptive Note:

Final rept. 1 Sep 2004-31 Aug 2006

Corporate Author:

TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO

Personal Author(s):

Report Date:

2006-09-01

Pagination or Media Count:

8.0

Abstract:

In a study of the mechanism behind the inhibitory effect of fish oil on the growth of breast cancer cells, the authors reported that fish oil, or w-3 polyunsaturated fatty acids PUFAs, did the following 1 increased the level of tumor suppressor protein PTEN 2 inhibited the activity of PI 3 kinase, thus blocking a potent growth promoting signaling pathway and 3 increased gene expression of BMP-2. In their final report, they show that a fish oil diet significantly increased the signals leading to breast cancer cell apoptosis. The tumors arising within the animals fed a fish oil diet have decreased expression of antiapoptotic Bcl-2 and BclXL, increased expression of cytochrome-c, and activation of caspase 3, indicating increased apoptosis. Results from their in vivo pilot study that used a nude mouse heart injection model suggest that a fish oil diet also can slow down bone metastasis of the breast cancer cells. Based on their previous report, they performed a pilot in vivo experiment to study the role of BMP-2 on bone metastasis. The data suggest that BMP-2 can inhibit bone metastasis. However, the in vivo data need to be verified using a larger animal pool and statistical analysis.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Food, Food Service and Nutrition

Distribution Statement:

APPROVED FOR PUBLIC RELEASE