Accession Number:

ADA463973

Title:

The Role of c-FLIP(L) in Regulating Apoptotic Pathways in Prostate Cancer

Descriptive Note:

Annual rept. 15 Nov 2005-14 Nov 2006

Corporate Author:

BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA

Personal Author(s):

• Olumi, Aria F.

Report Date:

2006-12-01

Pagination or Media Count:

103.0

Abstract:

Abnormalities in programmed cell death apoptosis machinery play a crucial role in initiation progression and metastasis of prostate cancer. Therefore molecules that initiate pro-apoptotic pathways are excellent therapeutic agents in prostate cancer. However some prostate cancer cells develop resistance to pro-apoptotic agents. In this proposal we are examining the regulatory mechanisms of c-FLIPL which is an important modular of apoptosis in prostate cancer.

Descriptors:

• *PROSTATE CANCER
• COMPUTER PROGRAMMING
• MOLECULAR BIOLOGY
• GENETIC ENGINEERING
• DEATH
• APOPTOSIS
• CELLS(BIOLOGY)
• ABNORMALITIES
• METASTASIS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE