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Nitric Oxide Generating Polymeric Coatings for Subcutaneous Glucose Sensors

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Annual rept. 15 Sep 2005-14 Sep 2006

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Heretofore, efforts to develop implantable chemical sensors for real-time clinical monitoring of glucose subcutaneously SQ in diabetic patients have been stymied by the unreliable analytical results owing largely to biocompatibility problems induced by sensor implantation e.g., inflammatoryforeign body response. The goal of this research program is to explore and optimize the chemistries required to fabricate implantable amperometric glucose sensors with outer polymeric coatings that slowly generate low levels of nitric oxide NO. The local generation of NO has been shown to enhance the biocompatibility of the implanted sensors by decreasing the inflammatory response. The focus of this research has been to develop new polymeric coatings biomedical hydrogels and polyurethanes that possess immobilized copper ion sites that will serve as catalytic surfaces for in situ conversion of endogenous nitrosothiol species RSNO e.g., nitrosoglutathione, nitrosocysteine, etc. to NO, thereby providing a local sustained generation of NO species at the surface of the implanted sensors. Preliminary experiments indicate RSNO levels within the SQ fluid of rats are sufficiently generate local NO to reduce the inflammatory response at the implantation site, using test devices coated with polymers containing immobilized copper ion sites. Finally, functional needle type SQ glucose sensors were prepared to demonstrate appropriate analytical performance for glucose measurements. These sensors will provide the basis of assessing if NO generation chemistries are compatible with glucose sensing chemistry

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Miscellaneous Detection and Detectors

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