Dietary Genistein and Prostate Cancer Chemoprevention
Final addendum 1 Apr 2005-31 Mar 2006
ALABAMA UNIV IN BIRMINGHAM
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The goal of our research was to determine if there is a developmental window for suppressing prostate cancer with the phytoestrogen genistein and its mechanism s of chemoprevention. Life-time starting at birth exposure to genistein was more effective in suppressing chemically-induced prostate cancer in rats than neonatallprepubertal or adult only exposures to genistein. Neonatallprepubertal genistein exposure did not alter prostate bud development. Dietary genistein during the neonatallprepubertal period as well as during adulthood resulted in decreased androgen receptor but not estrogen receptors alpha and beta in dorsolateral prostates of 70 day old rats suggesting that early exposure to genistein can have a programming effect on androgen receptor expression. However genistein at each period of postnatal development did not alter androgen receptor mRNA in the prostate data that argues against genistein causing gene silencing via DNA methylation mechanism in the prostate of rats. On the other hand genistein in the diet resulted in increased apoptosis in the prostate. Phospho-Akt and Bcl-2 protein levels were decreased and Bax was increased in prostates of rats fed genistein in tIle diet protein regulation consistent with increased apoptosis a cellular mechanism that can suppress prostate cancer development.
- Anatomy and Physiology
- Medicine and Medical Research