Accession Number:

ADA463929

Title:

EGFR-Dependent Regulation of Matrix-Independent Epithelial Cell Survival

Descriptive Note:

Final rept. 15 Mar 2002-14 Mar 2006

Corporate Author:

THOMAS JEFFERSON UNIV PHILADELPHIA PA

Personal Author(s):

Report Date:

2006-04-01

Pagination or Media Count:

32.0

Abstract:

Background Signaling through the epidermal growth factor EGFR has been implicated in both effective wound healing and epithelial neoplasia. We have identified a novel function of the EGFR in support of epithelial cell survival, particularly in conditions of anchorage-independence. ObjectiveHypothesis Define molecular mechanisms and pathways by which EGFR activation supports epithelial cell survival. Two specific aims focus on 1 posttranslational modification of relevant Bcl-2 family members by EGFR activation through MAPK-dependent mechanisms and, 2 STAT3 activation by deregulated EGFR signaling as observed in epithelial cancer. Progress Significant progress relating to Specific Aim I has included Publication of results in support of BIM regulation by the EGFR in normal and transformed keratinocytes Appendices included Characterization of a role of NF-KB activation in keratinocyte survival in the absence of extracellular matrix interaction and Pro-apoptotic signals by JNK and p38 activation in the anchorage-independent state are counteracted by NF-kB activity. We have completed the work proposed in Specific Aim 2.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE