Breast Cancer Risk in Relation to Urinary Estrogen Metabolites and Their Genetic Determinants: A Study Within the Dutch "DOM" Cohort
Final addendum rept. 1 Sep 2005-31 Aug 2006
INTERNATIONAL AGENCY FOR RESEARCH ON CANCER LYONS (FRANCE)
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Purpose and scope we are conducting a large case-control study nested within the Dutch DOM prospective cohort to estimate relative risk of breast cancer in post-menopausal women by levels of urinary estrogens and estrogen metabolites. Progress report in this year of extension of the project we finalized the setting up of our sensitive NCI GCMS method for the measurement of estrogen metabolites in urine samples. By using this method we performed these measurements on 145 breast cancer cases and 145 matched controls. Conclusions On the first set of data concentrations of 2-hydroxy estrone 2-methoxy estrone and the ratio between 2-hydroxy estrone and 16-alpha hydroxy estrone were significantly associated with breast cancer risk in post-menopausal women. We plan to complete the analyses on the samples from the whole nested case-control study by April 2007 i.e. beyond the extension limits of this grant and using internal IARC funds. A manuscript will then be prepared reporting the relationships of the urinary hormone levels with breast cancer risk.
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