PSMA-Targeted Nano-Conjugates as Dual-Modality (MRI/PET) Imaging Probes for the Noninvasive Detection of Prostate Cancer
Annual rept. 15 Sep 2005-14 Sep 2006
TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS
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The goal of this project is to develop dual modality imaging probes for the detection of prostate cancer by doping radioisotopes to iron oxide nanoparticle, so that the sensitivity and specificity of prostate cancer diagnosis could be significantly improved. In the first year, we successfully developed standard procedures to reproducibly prepare dextran-coated iron oxide nanoparticles with desired particle size DLS7.5 - 35 nm and size distribution 1-5 nm among the reaction condition variables, we found that the iron concentration plays the most important role in the nanoparticle formation. The high stability of the prepared particles was exhibited by a series of DLS measurements showing negligible aggregation or disintegration out to 10 days in water. By slightly modifying the synthetic conditions, we have doped three radioisotopes into the iron oxide core of the dextran-coated nanoparticles at high incorporation rates 50. The radioisotope-doped nano-platforms will be use for the development of MRIPET amd MRISPECT dual modality imaging probes in the following two years.
- Medicine and Medical Research