Intelligent Sensing and Probing with Applications to Protein NMR Spectroscopy and Laser Chemistry
Final rept. 1 Jul 2005-30 Jun 2006
PRESIDENT AND FELLOWS OF HARVARD COLL CAMBRIDGE MA OFFICE OF SPONSORED RESEARCH
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The main theme of the grant has been to study design of input probe signals for robust system identification. We have used these methods for design of pulse sequences in NMR spectroscopy that are robust to inhomogeneity and dispersion in the parameters of the system of interest. We have developed control theoretic methods which allow control of nuclear spins in presence of extreme inhomogeneities. We have shown that these new nonlinear control methods for probe design and system identification are an enabling technology for NMR and MRI in inhomogeneous fields, making mobile NMR and MRI systems practical. Such a system can serve multiple roles in a combat situation including diagnosis of head injury and trauma, detection of explosives and scanning metabolites in the living tissue.
- Atomic and Molecular Physics and Spectroscopy