Preclinical Mouse Models of Neurofibromatosis
Annual rept. 30 Sep 2005-29 Sep 2006
CALIFORNIA UNIV SAN FRANCISCO
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This report describes the sixth year of research, and the first under this award, by a Consortium of investigators who have been continuously funded by this Program to develop, characterize, and utilize strains of mice that accurately model tumors found in persons with NF1 and NF2. This Consortium has generated many novel models of NF1 and NF2-associated tumors and has exploited these strains to investigate biologic and preclinical questions. In this fund year, the Consortium organized a scientific conferences on the on the use of mouse models of NF-associated tumors to test new therapies, which resulted in a review article that addressed this general topic with specific reference to NF. The investigators have collaborated closely with each other and have shared expertise and reagents extensively. This NF Consortium is a member of the Mouse Models of Human Cancer Consortium of the National Cancer Institute and is participating fully in the activities of the group.
- Anatomy and Physiology
- Medicine and Medical Research