Accession Number:

ADA463399

Title:

ERalpha and ErbB-2 Cross-talk in Mammary Tumorigenesis and Metastasis

Descriptive Note:

Final rept. 31 Mar 2003-30 Mar 2006

Corporate Author:

MCGILL UNIV MONTREAL (QUEBEC)

Personal Author(s):

Report Date:

2006-04-01

Pagination or Media Count:

12.0

Abstract:

The induction of human breast cancer involves the complex interplay of hormones and growth factor receptors. The major focus of our DOD sponsored research program is to investigate the interaction of the ER and erbB-2 receptor in the induction of breast cancer. In addition, we studied the involvement of ErbB-2 coupled signaling pathways such as c-Src in ER induced mammary tumorigenesis. To accomplish this, we derived and characterized transgenic mice that expressed high levels of ER in the mammary epithelium. To explore the significance of ErbB-2 and c-Src in mammary tumor progression, we generated cohorts of bigenic mice expressing MMTV-ER along with ErbB-2, c-Src or Akt-1. The results of these analyses did not show any influence of the expression of an activated form of ER on ErbB-2 induced mammary tumor formation. No evidence of c- Src or Akt-1 acting synergistically with ER to accelerate mammary tumor progression has been observed either.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE