Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma
Annual rept. 1 Jun 2005-31 May 2006
FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
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The association between SNCG expression and the progression of steroid dependent cancers of breast and ovary promoted us to investigate the role of SNCG in regulation of ERalpha. SNCG strongly stimulated the ligand-dependent transcriptional activity of ERalpha in breast cancer cells. A notable finding relevant to this study is that SNCG, acting as a chaperone for ER, strongly stimulated the ligand-dependent transcriptional activity of ERalpha, ligand-dependent cell growth, and ligand-dependent mammary tumorigenesis. Augmentation of SNCG expression stimulated the transcriptional activity of ERalpha and ligand-dependent growth, whereas compromising endogenous SNCG expression suppressed ERalpha signaling and ligand-dependent growth.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research