Accession Number:

ADA462917

Title:

Targeting Stromal Recruitment by Prostate Cancer Cells

Descriptive Note:

Annual summary rept. 15 Feb 2004-14 Feb 2006

Corporate Author:

WISCONSIN UNIV-MADISON

Personal Author(s):

Report Date:

2006-03-01

Pagination or Media Count:

54.0

Abstract:

Sonic hedgehogshhoverexpression in LNCaP cells accelerates tumor growth. To characterize the contributions of each Gli gene to Shh-induced tumor growth, Gli1, Gli2 and Gli3 knockout UGSM cells have been isolated and UGSM-2 cells independently over-expressing hGli1 and hGli2 were cloned. Experiments using those cell lines co-injected with LNCaP cells in the Xenograft model indicate stromal Shh signaling activation may play an important role in the tumor growth.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE