Targeting Stromal Recruitment by Prostate Cancer Cells
Annual summary rept. 15 Feb 2004-14 Feb 2006
Pagination or Media Count:
Sonic hedgehogshhoverexpression in LNCaP cells accelerates tumor growth. To characterize the contributions of each Gli gene to Shh-induced tumor growth, Gli1, Gli2 and Gli3 knockout UGSM cells have been isolated and UGSM-2 cells independently over-expressing hGli1 and hGli2 were cloned. Experiments using those cell lines co-injected with LNCaP cells in the Xenograft model indicate stromal Shh signaling activation may play an important role in the tumor growth.
- Medicine and Medical Research