Accession Number:

ADA462488

Title:

Identification and Characterization of Prostate Cancer Associated Protein Biomarkers Using High-Throughput Mass Spectrometry

Descriptive Note:

Annual rept. 15 Nov 2005-31 Aug 2006

Corporate Author:

EASTERN VIRGINIA MEDICAL SCHOOL NORFOLK

Personal Author(s):

Report Date:

2006-09-01

Pagination or Media Count:

56.0

Abstract:

Prostate cancer PCa remains to be the most common non-skin cancer in the US. Currently available screening tests for PCa including prostate specific antigen PSA test, digital rectal examination DRE and prostate biopsy, call for more accurate and non-invasive techniques to detect, diagnose, and stratify the disease based on molecular markers present in the body fluids. There has been an impressive emergence of mass spectrometry based technologies applied toward the study of such biomolecular markers of disease states. Our focus on utilization of such techniques towards prostate cancer will promise a better health and future for PCa patients. We have devised strategies to isolate and identify protein biomarkers from PCa patients in the clinical gray-area where PSA fails to detect cancer. Identification of such cancer biomarkers will assist in development of better non-invasive diagnostic tools for prostate cancer and may also lead to better therapeutic targets.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE