Chemoprevention of Ovarian Cancer
Final rept. 1 Oct 1999-30 Sep 2006
M D ANDERSON CANCER CENTER HOUSTON TX
Pagination or Media Count:
The overarching hypothesis of this program project has been that 4-HPR a synthetic vitamin A and oral contraceptives OCP induce apoptosis, possibly through induction of TGF production by stromal cells, as well as by direct interaction with the surface epithelial cells, and these two cell types may act synergistically. In Project 1, 19 adult Rhesus monkeys were given 4- HPR, OCP, the combination, or no medication for 3 months. There were consistent differences in the absolute fluorescence intensities and relative contributions noted between pre- and post-drug measurements in each drug group. A second study involving 30 Cynomolgus macaques and using a crossover design has been completed immunohistochemical analysis of several biomarkers and analysis of the fluorescence spectroscopy data are ongoing. Project 2 was transferred to the University of Arizona with the relocation of Dr. Molly Brewer in 2001. This project was not able to be completed related to multiple regulatory issues and inadequate patient accrual. In Project 3, we have focused on understanding the mechanism of action of 4-HPR in tissue culture using both normal and immortalized epithelial cells. Studies are now complete.
- Medicine and Medical Research