Accession Number:

ADA461957

Title:

Long Term Outcomes of BRCA1/BRCA2 Mutation Testing

Descriptive Note:

Annual rept. 21 Jul 2005-20 Jul 2006

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

2006-08-01

Pagination or Media Count:

10.0

Abstract:

This project aims to gain a better understanding of the implications of genetic testing for breast-ovarian cancer susceptibility. The primary goal is to evaluate the impact of BRCA1BRCA2 mutation testing on long term psychosocial quality of life, distress, social functioning and preventionsurveillance mammography, CA125, transvaginal ultrasound, prophylactic mastectomy, prophylactic oophorectomy and chemoprevention outcomes. To accomplish this we will measure outcomes within a group of women who received BRCA1BRCA2 test results at least four years ago. We will divide our sample based upon their personal cancer history - evaluating cancer survivors with different measures compared to unaffected individuals. For both survivors and unaffected individuals we will recruit separate comparison samples of women who have never received BRCA1BRCA2 testing. During this past year we received final approval from the DOD to begin accrual. We have initiated accrual and to date have completed follow-up interviews with xxx women. During the upcoming year we will continue accrual of our genetic testing cohort and will initiate accrual of our comparison groups.

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE