Biomarkers of Selenium Action in Prostate Cancer
Annual summary rept. 1 Jan 2004-28 Feb 2006
STANFORD UNIV CA
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This study was designed to identify new, mechanistically relevant biomarkers of selenium responsiveness for use in intervention trials. We have characterized the global transcriptional response of LNCaP prostate cancer cells to selenium by using cDNA microarray. We have identified molecular targets of selenium that are secretory using bioinformatics approaches and datasets of selenium modulated transcripts and membrane bound and secretory proteins. To help prioritizing biomarker candidates, we have cross-referenced the selenium modulated genes list with existing prostate cancer microarray data sets. Using this approach, we have narrowed down the number of biomarker candidates that we are now characterizing in more details.
- Medicine and Medical Research