Chamber Tests with Human Subjects XX. Hypersensitivity to H as Demonstrated by Patch Tests Before and After Chamber Exposure to H Vapor
NAVAL RESEARCH LAB WASHINGTON DC CHEMISTRY DIV
Pagination or Media Count:
A series of sensitivity tests on men before and after exposure to H vapor is described in this report. Doses of 1, 12, 14, and 18 micrograms of H in mineral oil, worn as closed patches on the forearm for four hours, represented a satisfactory subvesicant level for determining altered sensitivity. The intensity of reaction to patch tests by previously unexposed men showed a marked variation directly proportional to the outside effective temperature at the time the patches were worn. In addition to erythema, edema andor folliculitis were observed in only 2 of 230 men tests prior to exposure to H vapor. After exposure, 26 of 169 men manifested edema andor folliculitis to patch tests. These men were arbitrarily considered sensitized This sensitized group also showed a more intense erythema for each does and a lower threshold dose for perceptible erythema than the non-sensitized group. Cases of abnormal generalized skin reaction following exposure to H vapor in the man-chamber are discussed. Eight kodachrome prints, illustrating pertinent features, are included.
- Weapons Effects (Biological)
- Test Facilities, Equipment and Methods
- Chemical, Biological and Radiological Warfare
- Protective Equipment