Accession Number:

ADA461618

Title:

Chamber Tests with Human Subjects XX. Hypersensitivity to H as Demonstrated by Patch Tests Before and After Chamber Exposure to H Vapor

Descriptive Note:

Corporate Author:

NAVAL RESEARCH LAB WASHINGTON DC CHEMISTRY DIV

Report Date:

1946-05-15

Pagination or Media Count:

53.0

Abstract:

A series of sensitivity tests on men before and after exposure to H vapor is described in this report. Doses of 1, 12, 14, and 18 micrograms of H in mineral oil, worn as closed patches on the forearm for four hours, represented a satisfactory subvesicant level for determining altered sensitivity. The intensity of reaction to patch tests by previously unexposed men showed a marked variation directly proportional to the outside effective temperature at the time the patches were worn. In addition to erythema, edema andor folliculitis were observed in only 2 of 230 men tests prior to exposure to H vapor. After exposure, 26 of 169 men manifested edema andor folliculitis to patch tests. These men were arbitrarily considered sensitized This sensitized group also showed a more intense erythema for each does and a lower threshold dose for perceptible erythema than the non-sensitized group. Cases of abnormal generalized skin reaction following exposure to H vapor in the man-chamber are discussed. Eight kodachrome prints, illustrating pertinent features, are included.

Subject Categories:

  • Weapons Effects (Biological)
  • Test Facilities, Equipment and Methods
  • Chemical, Biological and Radiological Warfare
  • Protective Equipment

Distribution Statement:

APPROVED FOR PUBLIC RELEASE