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PCBs, Liver Lesions, and Biomarker Responses in Adult Walleye (Stizostedium vitreum vitreum) Collected from Green Way, Wisconsin

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Adult walleye were collected from several locations in the Lower Fox River and Green Bay, Wisconsin the assessment area and two relatively uncontaminated reference locations Lake Winnebago and Patten Lake, Wisconsin between July and October in 1996 and 1997. Whole body and liver samples collected in 1996 were analyzed for total PCBs, PCB congeners, and liver histological lesions. Follow-up sampling in 1997 included examination of liver histopathology, PCBs in liver samples, measurement of ethoxyresorufin-O-deethylase EROD activity, immunological evaluation of kidney and blood samples, measurement of plasma vitellogenin, and examination of tissues for parasites as well as bacterial and viral infections. Mean PCB concentrations in whole body and liver samples were elevated in assessment area walleye 4.6 to 8.6 and 3.6 to 6.4 mgkg wet weight, respectively compared to PCB concentrations in reference areas 0.04 mgkg in walleye fillets from Lake Winnebago. A significant p 0.01 elevation was observed in the prevalence 26 of hepatic preneoplastic foci of cellular alteration FCA and neoplasms in 5 to 8 year old walleye collected from the assessment area, compared to reference area fish 6 prevalence. Walleye from the assessment area also contained multiple FCA and hepatic tumors per liver sample, whereas no tumors and a reduced prevalence of FCA were observed in reference area walleye. Both tumors and FCA were more prevalent in female fish than in male fish within the 5 to 8 year age classes. The data did not show any clear distinctions in the prevalence of disease between reference and assessment area walleye. The results of this investigation demonstrate significant elevation in hepatic preneoplastic lesions and hepatocellular adenomas and carcinomas in assessment areas walleye exposed to elevated concentrations of PCBs.

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  • Animal Husbandry and Veterinary Medicine
  • Biology
  • Water Pollution and Control

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