DNA Conforming Dynamics and Protein Binding
Technical rept. 15 Aug 2005-14 Aug 2006
TEXAS UNIV AT BROWNSVILLE AND TEXAS SOUTHMOST COLLEGE
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Recent advances in singlemolecule force spectroscopy of DNA make it possible to study the thermodynamics and kinetics of DNA binding proteins under a wide range of conditions. A biophysical model for the DNA binding T4 gene 32 protein has been developed to study the kinetics of DNA protein binding to transient single-stranded DNA regions due to thermal fluctuations. The model is used to analyze recent single-molecule spectroscopy data of this system.
- Genetic Engineering and Molecular Biology