Mammary Stromal Effects on Epithelial Differentiation and Expression of ESX and ErbB2
Annual summary rept. 20 Aug 2001-19 Aug 2004
CALIFORNIA UNIV SAN FRANCISCO
Pagination or Media Count:
A novel system for studying growth of normal human mammary epithelium in vivo as grafts in athymic nude mice has been developed. The key feature of this mode is the reconstitution of the epithelial-stromal interactions that occur in the normal human breast. This model has been used to demonstrate the ability of carcinoma associated fibroblasts to cause abnormal growth of normal human mammary epithelium. The renal grafting technique has also been used to study tumor growth and tumor inhibition.
- Anatomy and Physiology
- Medicine and Medical Research