CBP and Extracellular Matrix-Induced Apoptosis in p53(-) HMECs: A Model of Early Mammary Carcinogenesis
Final rept. 1 Sep 2002-31 Aug 2006
DUKE UNIV MEDICAL CENTER DURHAM NC
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Interactions between normal mammary epithelial cells HMECs and extracellular matrix ECM are important for mammary gland homeostasis and loss of ECM-sensitivity is an early event in mammary carcinogenesis. The purpose of this grant is to investigate how the CREBP-binding protein CBP might target the elimination of damaged HMECs. We have observed that 1 suppression of CBP results in apoptosis-resistance through impaired laminin expression and 2 CBP promotes induction of interferon-regulated genes during apoptosis. These findings will provide novel targets for chemoprevention and are being used to develop markers for response to current prevention strategies.
- Medicine and Medical Research