Accession Number:

ADA460834

Title:

CBP and Extracellular Matrix-Induced Apoptosis in p53(-) HMECs: A Model of Early Mammary Carcinogenesis

Descriptive Note:

Final rept. 1 Sep 2002-31 Aug 2006

Corporate Author:

DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s):

Report Date:

2006-09-01

Pagination or Media Count:

129.0

Abstract:

Interactions between normal mammary epithelial cells HMECs and extracellular matrix ECM are important for mammary gland homeostasis and loss of ECM-sensitivity is an early event in mammary carcinogenesis. The purpose of this grant is to investigate how the CREBP-binding protein CBP might target the elimination of damaged HMECs. We have observed that 1 suppression of CBP results in apoptosis-resistance through impaired laminin expression and 2 CBP promotes induction of interferon-regulated genes during apoptosis. These findings will provide novel targets for chemoprevention and are being used to develop markers for response to current prevention strategies.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE