Use of Exogenous Progestins and Risk of In Situ and Invasive Breast Cancer
Annual rept. 15 Sep 2005-14 Sep 2006
FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA
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Given the large number of women exposed to progestins through either contraceptives or menopausal hormone therapies, clarifying the etiologic role of progestin in relation to breast cancer is of public health importance. This studys two projects will further our understanding of the potential risk of breast cancer associated with progestin use. Project 1 involves the enrollment of 225 in situ breast cancer cases 20-44 years of age. Project 2 is a case-control study of women 55-74 years of age that will enroll 325 controls and 975 breast cancer cases 325 each of three different histologic types of breast cancer. Both projects involve a detailed in-person interview and review and testing of tumor samples for various tumor markers. There are no major findings from this study as subject ascertainment has not yet begun. This year has been spent entirely on trying to obtain human subjects approval from DOD, and since approval has not yet been granted, no participants have been enrolled.
- Medicine and Medical Research