Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH
Final rept. 30 Sep 2004-29 Sep 2006
GEORGETOWN UNIV WASHINGTON DC
Pagination or Media Count:
The sentinel lymph node SLN is the first node in the mammary gland to harbor malignant cells in breast tumors with metastasis, and SLN positivity is an indication for axillary lymph node dissection. The purpose of our study is to identify specific genetic alterations using array-CGH in the metastatic sentinel lymph node lesions, in comparison to the one observed in the corresponding primary tumors from patients with breast cancer. We believe that the characterization of genetic alterations at the SLN site is a logical step to define the cytogenetic evolution of primary tumors to a metastatic state, and my represent the initial genetic events that occur in the early metastatic process, before distant metastasis occur. Ultimately these reduction or elimination of the need for invasive surgical procedures, such as axillary dissection, in the management of breast cancer patients.
- Anatomy and Physiology
- Medicine and Medical Research