Epigenetic Regulation of Chemokine Expression in Prostate Cancer
Annual rept. 1 Dec 2005-30 Nov 2006
PITTSBURGH UNIV PA
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During the first year of support, we developed a marked progress toward the main goal of our proposal - understanding the mechanisms of chemokine regulation in prostate cancer. Specifically, we revealed that prostate cancer cell lines and tissues obtained from cancer patients express low or no CSCL14 chemokine protein and mRNA, which might results in low infiltration of the tumor mass by dendritic cells. Importantly, if dendritic cells are not attracted to the prostate cancer tissues, no antitumor immune responses may be generated due to the absence of tumor antigen recognition, processing and presentation. These fundamental findings will now allow us to move forward and investigate the biological significance of these findings and the mechanisms of CSCL14 regulation in tumor cells.
- Anatomy and Physiology
- Medicine and Medical Research