Evaluation of Chemicals for Antimalarial Activity Against Blood and Tissue Stages
Annual rept. 14 Mar 2004-31 May 2005
MIAMI UNIV FL
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Three different test systems were used to detect antimalarial activity of new compounds in mice. The first test AT Test detected activity against blood stage parasites Thompson Test. There were 105 three level tests done plus 3 one level tests performed. 54 compounds exhibited activity against the asexual blood stages. The 2 most active compound were BQ 99377 and BR 01050. The second test SM Test detected activity against the sporozoite stages or the exoerythrocytic schizont stages in the liver. There were 66 three level tests done where the drug was given once and 2 tests where the drugs were given for 3 days. The most active compounds were BQ 11373, BQ 93713, BQ 93722, BH 50615, BH 58522 and BR 01069. There were 18 SM tests done to detect synergistic activity between Primaquine and methylene blue, Atovaquone, Proguanil, Dapsone, Quinine, BQ 98852 and Doxycycline. The third test detects activity against the gametocyte stages. There were 121 compounds tested. The one oracle database was used to tabulate and analyze data from both the AT and SM test systems.
- Medicine and Medical Research