Polyphenois and Prostate Cancer Chemoprevention
Annual rept. 1 Mar 2005-28 Feb 2006
ALABAMA UNIV IN BIRMINGHAM
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The goal of this research is to investigate the potential of resveratrol genistein and - epigallocatechin-3-gallate EGCG, alone in combination, to protect against prostate cancer in a transgenic rat model TRAMP. The specific aims are 1 to investigate the potential of genistein, EGCG and resveratrol, alone and in combination, to suppress the development of spontaneously developing prostate tumors and 2 to investigate the potential of these polyphenols to regulate sex steroid - and specific growth factor-receptor and ligand expression as mechanism of prostate cancer prevention. To date, we have demonstrated that pure resveratrol in the diet, but not EGCG in the water, suppressed spontaneously developing prostate tumors in TRAMPs. Androgen and estrogen receptors and EGF.IGF-1, and ERK signaling pathways are differentially regulated in both the DLP and VP of genistein, resveratrol and EGCG treated mice. We are in the process of investigating combinational genistein and resveratrol treatments to suppress prostate cancer in TRAMPs and to investigate mechanisms of action in mice treated with these 2 polyphenols.
- Medicine and Medical Research