Accession Number:

ADA460477

Title:

Estrogen Metabolism and Prostate Cancer Risk: A Prospective Study

Descriptive Note:

Annual rept. 1 May 2005-30 Apr 2006

Corporate Author:

ITALIAN NATIONAL CANCER INST REGINA ELENA ROME (ITALY)

Personal Author(s):

Report Date:

2006-05-01

Pagination or Media Count:

26.0

Abstract:

Prostate cancer is the most common cancer among men in the United States and the second most common in the European Community. The causes of prostate cancer, however, remain largely unknown, with age, race, and family history being the only established risk factors. The prostate gland has historically been considered the prototype of an androgen-dependent organ. However, there is evidence that estrogens may induce mitosis of prostatic epithelial cells in many species, including humans. This report analyzes the association between prostate cancer and estrogen metabolism in a case-control study. In particular, the authors tested the hypothesis that the pathway favoring 2-hydroxylation over 16alpha-hydroxylation may be associated with a decrease in prostate cancer risk. This is the annual report for the third year of the study. During the third year of activity, the authors completed the definition of the large data set of the study, conducted quality control procedures on the collected data, and developed new laboratory procedures for the determination of the estrogen metabolites using gas-chromatography. The hormone determinations are now in an advanced phase of progress.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE