Prostate Derived Ets Factor, an Immunogenic Breast Cancer Antigen
Annual rept. 1 Sep 2005-31 Aug 2006
HEALTH RESEARCH INC BUFFALO NY
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The goal of the proposed research was to test the following concept. Due to prostate restricted expression of Pse in normal tissues of mice, Pse is likely to be immunogenic in female mice. T cell responses of male and female mice to Pse and a control antigen Her-2neu were compared. Two different assays were used for this purpose the ELISPOT assay and the Cytotoxicity assay. To date, we have found that in the FVB strain of mice immunization with Pse induces specific T cell responses in female mice but not in male mice. In contrast, Her-2neu is immunogenic in both female and male mice. These results are novel and significant and they support our concept and suggest that PDEF the human homologue of Pse is likely to be similarly immunogenic in female breast cancer patients. Our results also suggest that lack of immunogenicity of Pse in male mice is likely due to some mechanism of tolerance to a self protein since PsePDEF is strongly expressed in the normal prostate tissue of males.
- Medicine and Medical Research