Accession Number:

ADA460050

Title:

Fully Virulent Bacillus Anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis

Descriptive Note:

Journal article

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD VIROLOGY DIV

Report Date:

2006-10-20

Pagination or Media Count:

5.0

Abstract:

The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant bclA of the fully virulent Ames strain. This derivative retained full virulence in several small animal models of infection despite the bclA deletion.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE