Fully Virulent Bacillus Anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD VIROLOGY DIV
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The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant bclA of the fully virulent Ames strain. This derivative retained full virulence in several small animal models of infection despite the bclA deletion.
- Medicine and Medical Research